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ACEing Biochemistry Vol. 1

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omarys's version from 2018-02-06 11:26

Section 1: What's ACE, precious?

Question Answer
ACEAngiotensin-converting enzyme (converts angiotensin I to its active form, angiotensin II)
ACEi (ACE inhibitors)decrease AII levels = less "angio tensing" = decrease blood pressure
memorize

Section 2: Proteins I - General

Question Answer
NaturaL amino acids are always in the _________ configuration.L
Acidic (low) pH = high H+ concentration = Both the _________ and _________ groups are _________. The opposite is true for basic pH.carboxyl ; amino ; protonated
The "simplest" amino acid is _________, wherein the R group is a _________. This renders the amino acid not _________ (there're 2 _________ attached to the alpha carbon), and therefore not _________.glycine ; hydrogen atom ; chiral ; (hydrogens) ; optically active
Nonpolar, hydrophobic amino acids- (think LIPids, hydrophobic like lipids)aLIPhatic AA
Amino acids that contain a benzene ring (think aroma as benzene smells nice)aromatic AA
AA with a carboxyel group can undergo _________, which modifies the function ("on/off switch") of the entire protein.phosphorlation (OH, I like to Pee)
Cys = cis = same = Same Sex = SScysteine likes disulfide (SS) bonds
Proline is a pro _________ (not a boring hydrophobic one) bc it has a _________ around the alpha carbon and can affect the _________ of the protein.aliphatic ; ring ; 3D structure
Major post-translational modifications (PH for PH, C for C)-PHosphorylation for PHunctionality (activates or deactivates protein), Carboxylation usually for Coagulation processes, hydroxylation for whatever
Significance of the number 1 for the carboxyl group in an amino acid-its pK is pK1 ; it tends to give its proton 1st (before the amino group), i.e. at lower pH
memorize

Section 3: Proteins II - Enzymes

Section 4: Proteins III - Enzymes, cont.

Section 5: Review