316 Q4

ndifranco94's version from 2015-09-08 03:04


Question Answer
Electrolytessubstances that yield ions when dissolved in water, conduct an electric current through solution
Strong electrolytescomplete dissociation (NaCl, Na2SO4)
Weak electrolyteespartial dissociation (HF, Aspirin)
Solvationinteraction of a solute w/ solvent, leads to stabilization of solute in soln
Electrolyte form a drugbetter water solubility than free form
Colligative propsvapor pressure lowering, boiling pt elevation, freezing pt lowering, osmotic pressure
Difference of osmotic pressure for electrolyteosmotic coefficient "i" for # of ions in soln
Acftivityeffective concentration of ions in soln
Activity coefficientmeasure of how activity differs from stoichiometric values b/c ions do not completely dissociate
As concentration goes up, activity coeff typicallydecrease, but sometimes they increase
Osmolality# of particles/1kg of water
Osmolarity# of paticles/1L of water
Tonicityosmotic pressure gradient of 2 solns separated by semipermeable membrane
Hypertonicgreater conc of solute outside cell, water leaves cell and they shrink
Isotonicsame conc of solute inside/outside cell, no net passage of water through membrane
Hypotoniclower conc of solute outside cell, water enters cell and they burst
Pharmaceutical solns should have the same ___ as body fluid to be isotonicfreezing point
How to adjust tonicitymeasure freezing point depression of soln, calculate gap b/n soln and body, calc amt of solute needed to fill gap
Sodium chloride equivalent methodfind weight of NaCl w/ same freezing pt lowering as 1g of drug, use in freezing pt depression eqn

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