2016 Pharmacology Practice Questions

dermregperth's version from 2017-05-21 09:39



Sunscreens: Benzophenones & their spectrum of coverage


Regarding Psoralens / PUVA: Immunosuppression caused by PUVA induces malignancy: ** False
Regarding Psoralens / PUVA: DNA damage caused by PUVA induces malignancy: ** False


Regarding Botox: All serotypes are protein bound
Regarding Botox: All serotypes act on acetylcholine receptors at the neuromuscular junction
Regarding Botox: C serotype is minimally effective in humans


Contraindications of Botox: Body dysmorphic syndrome: ** True


Clindamycin: Acts on the bacterial cell wall: ** False


Chlorhexidine is ototoxic
Chlorhexidine is more effective than iodine
Triclosan is used on mucosal surfaces


Topical corticosteroids: IL, IKb & other pathways


Local anaesthetics: Mepivacaine is more cardiotoxic than other local anaesthetics
Local anaesthetics: Procaine has a shorter duration of action than lignocaine


Methotrexate is a nephrotoxin
Intramuscular methotrexate >15mg has unpredictable renal excretion


Anabolized to its active form 6-TG (purine analog) by the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
Dose adjustment required in liver failure
Crosses the blood brain barrier
6TG is the initial metabolite produced?


Cyclosporin: which drugs interact with it?


Calcium channel blockers: Nifedipine is contraindicated in patients with severe heart failure


Hydroxychloroquine: Reduced visual acuity indicates retinopathy


e.g. cellular mycotic function


Interferons: Undergo renal phagocytosis


Adalimumab: Anti-drug antibodies are associated with adverse effects


Spironolactone reduces 5 alpha reducase


Bleomycyn acts in the S phase
Bleomycin directly binds to the HPV virus
Bleomycin causes Raynaud’s only in the digits injected


5-FU is incorporated into cellular DNA
5-FU cause suppression of DNA


Salicylates have neurological side effects


Urea: Doses at 20% are keratinolytic
Urea: Nitrogen caused by urea increases bacterial growth


Tar: Is effective against melassezia


DDET: Children are at higher risk of side effects at greater concentrations than adults


Hepatotoxicity: Most reactions will reverse within 14 days


Topical agents: Mosel’s solution contains aluminium chloride
Aluminium chloride causes thrombin formation


Nicotinamide is Vitamin B3
Nicotinamide reduces mast cell degranulation
Nicotinamide topically suppresses cell turnover


Doxycycline causes photo-onycholysis
Doxycycline: can’t take it & lay down straight after


Acyclovir: Side effect is leukocytoclastic vasculitis


Bactroban contains propylene glycol


Shampoos: Propylene glycol is used as a cationic agent


Penicillins: Dicloxacillin should be taken with food
Dicloxacillin dose must be reduced in renal failure


Doxepin: Dosing starts at 100mg


Calcineuin inhibitors: have a small particle size
Drug interactions