Create
Learn
Share

2016 Pharmacology Practice Exam - November

rename
dermregperth's version from 2016-11-07 21:24

Questions

 

Sunscreens: Something about benzophenones & their spectrum of coverage

 

Regarding Psoralens / PUVA: Immunosuppression caused by PUVA induces malignancy: ** False
Regarding Psoralens / PUVA: DNA damage caused by PUVA induces malignancy: ** False

 

Regarding Botox: All serotypes are protein bound
Regarding Botox: All serotypes act on acetylcholine receptors at the neuromuscular junction
Regarding Botox: C serotype is minimally effective in humans

 

Contraindications of Botox: Body dysmorphic syndrome: ** True

 

Clindamycin: Acts on the bacterial cell wall: ** False

 

Chlorhexidine is ototoxic
Chlorhexidine is more effective than iodine
Triclosan is used on mucosal surfaces

 

Topical corticosteroids: Questions on IL, IKb & other pathways

 

Local anaesthetics: Mepivacaine is more cardiotoxic than other local anaesthetics
Local anaesthetics: Procaine has a shorter duration of action than lignocaine

 

Methotrexate is a nephrotoxin
Intramuscular methotrexate >15mg has unpredictable renal excretion

 

Azthathioprine:
Anabolized to its active form 6-TG (purine analog) by the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
Dose adjustment required in liver failure
Crosses the blood brain barrier
6TG is the initial metabolite produced?

 

Cyclosporin: which drugs interact with it?

 

Calcium channel blockers: Nifedipine is contraindicated in patients with severe heart failure

 

Hydroxychloroquine: Reduced visual acuity indicates retinopathy

 

One whole section on Glucocorticoids:
Can’t recall the questions
e.g. cellular mycotic function

 

Interferons: Undergo renal phagocytosis

 

Adalimumab: Anti-drug antibodies are associated with adverse effects

 

Spironolactone reduces 5 alpha reducase

 

Bleomycyn acts in the S phase
Bleomycin directly binds to the HPV virus
Bleomycin causes Raynaud’s only in the digits injected

 

5-FU is incorporated into cellular DNA
5-FU cause suppression of DNA

 

Salicylates have neurological side effects

 

Urea: Doses at 20% are keratinolytic
Urea: Nitrogen caused by urea increases bacterial growth

 

Tar: Is effective against melassezia

 

DDET: Children are at higher risk of side effects at greater concentrations than adults

 

Hepatotoxicity: Most reactions will reverse within 14 days

 

Topical agents: Mosel’s solution contains aluminium chloride
Aluminium chloride causes thrombin formation

 

Nicotinamide is Vitamin B3
Nicotinamide reduces mast cell degranulation
Nicotinamide topically suppresses cell turnover

 

Tetracycline
Doxycycline causes photo-onycholysis
Doxycycline: can’t take it & lay down straight after

 

Acyclovir: Side effect is leukocytoclastic vasculitis

 

Bactroban contains propylene glycol

 

Shampoos: Propylene glycol is used as a cationic agent

 

Penicillins: Dicloxacillin should be taken with food
Dicloxacillin dose must be reduced in renal failure

 

Doxepin: Dosing starts at 100mg

 

Calcineuin inhibitors: have a small particle size

 

A couple of whole sections on drug interactions: Can't recall the specifics but this drug reacts with this drug